I have been using the aforementioned motherboard with an Intel Q6600 CPU for a year and a half in a home theater PC environment. I have been mostly happy until now.
That was before I tried to use the Dynamic Energy Saver (DES) utility program that came with it. This program is supposed to reduce energy consumption. While I haven't tried to measure the savings, I noticed clicks and pops in the losslessly compressed classical music I was playing from iTunes. The SPDIF optical output of the motherboard was connected to my Yamaha RX-V2500 receiver . The Realtek drivers in Windows 7 were configured to output at 24 bits / 192 kHz by default.
Fortunately, the audio problem went away after disabling the DES. But this makes the DES less than useful.